Synthesis and Antimicrobial, Antiproliferative Evaluation of Novel Quinolone and Conazole Analogues via Conventional and Microwave Techniques

1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a–c). Their reaction with sodium hydroxide gave 1,2,4-triazole derivatives (7 Compound 3 treatment 2-bromo-1-(4-chlorophenyl) ethanone or 2-chloro-1-(2,4-dichlorophenyl)ethanone afforded compounds 8 a,b and by reducing these reduction products were obtained (9 a,b). The synthesis of (10 a–e) carried out 9 different benzyl chlorides. Then oxadiazole derivative (12) ring closure hydrazide compound 5. Subsequently 3, 7 a–c, 12 treated various amines in presence formaldehyde yield Mannich bases (11 a–e, 14 13 Microwave-assisted conventional techniques utilized for syntheses. structures newly synthesized illuminated spectroscopic methods. antimicrobial (MIC method), anticancer activities (Abay's method) examined. Results showed that most exhibited good activities. Especially a–e which is a mannich base very antitubercular activity against Mycobacterium smegmatis compared Streptomycin standard drug. Also b have been found strong antiproliferative effects on HeLa cervical cancer cells also did not cytotoxic normal cells.